Kineret

Generic Name: anakinra (Subcutaneous route)

an-a-KIN-ra

Commonly used brand name(s)

In the U.S.

• Kineret

Available Dosage Forms:

• Solution

Therapeutic Class: Immunological Agent

Pharmacologic Class: Interleukin-1 Inhibitor

Uses For Kineret

Anakinra is used to treat moderate to severe symptoms of rheumatoid arthritis. It may relieve redness, pain, tenderness, and warmth in hands, feet, wrists, shoulders, elbows, and ankles. This medicine is used in patients 18 years of age or older. Anakinra will not cure the disease, but will help with the symptoms as long as you continue to take it.

This medicine is available only with your doctor's prescription.

Before Using Kineret

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of anakinra in children with use in other age groups.

Geriatric

This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	B	Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Abatacept


• Adalimumab


• Certolizumab Pegol


• Etanercept


• Golimumab


• Infliximab


• Rilonacept

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Active infections—May be worsened by anakinra

• Asthma—Patients with asthma may be at higher risk of getting a serious infection when taking anakinra.

• Immunosuppression—Anakinra has not been studied in patients who have immune system problems. The effects of the medicine in these patients is not known

• Kidney disease—Higher blood levels of anakinra may occur

Proper Use of Kineret

Your health care professional will teach you or your caregiver how to give the injection. You must demonstrate the procedure so that your health care professional knows you understand. Before taking the injection, check the medicine to make sure it is clear and doesn't have any particles in it. If it looks cloudy or discolored, or has any particles floating in it, you should throw it away. Do not shake the syringe. Give the entire dose and then throw away the syringe. Your health care professional will tell you how to dispose of your syringes. Do not reuse syringes. Do not keep part of a dose for later use. Take the medicine at the same time each day. If you have questions or problems with the procedure, call your health care professional.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For injection dosage form
  
  • For rheumatoid arthritis:
    
    • Adults—100 milligrams (mg) a day injected under the skin.
    
    
    • Children—Use and dose must be determined by your doctor. Anakinra is not usually recommended for use in children.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store in the refrigerator. Do not freeze.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using Kineret

It is important that your doctor check your progress at regular visits to make sure that this medicine is working properly and to check for unwanted effects.

Your body's ability to fight infection may be reduced while you are being treated with anakinra, it is very important that you call your doctor at the first signs of any infection (for example, if you get a fever or chills).

While you are being treated with anakinra, do not have any immunizations (vaccinations) without your doctor's approval.

Kineret Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Chest pain


• cough


• diarrhea


• fever or chills


• general feeling of discomfort or illness


• headache


• itching, pain, redness, swelling, tenderness or warmth on skin


• joint pain


• loss of appetite


• muscle aches and pains


• nausea


• pain or tenderness around eyes and cheekbones


• redness, bruising pain at the injection site


• runny nose


• shivering


• shortness of breath


• sneezing


• sore throat


• sweating


• tightness in chest


• trouble sleeping


• unusual tiredness or weakness


• vomiting


• wheezing

Less common or rare

• Black, sticky stools


• difficulty in swallowing


• itching


• lower back pain or side pain


• painful or difficult urination


• pale skin


• rash; hives; swelling of face or lips


• ulcers, sores or white spots in mouth


• unusual bruising or bleeding

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Abdominal or stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Kineret side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

More Kineret resources

• Kineret Side Effects (in more detail)
• Kineret Use in Pregnancy & Breastfeeding
• Kineret Drug Interactions
• Kineret Support Group
• 4 Reviews for Kineret - Add your own review/rating

• Kineret Prescribing Information (FDA)


• Kineret Consumer Overview


• Kineret Monograph (AHFS DI)


• Kineret MedFacts Consumer Leaflet (Wolters Kluwer)


• Anakinra Professional Patient Advice (Wolters Kluwer)

Compare Kineret with other medications

• Rheumatoid Arthritis
• Schnitzler Syndrome
• Still's Disease

Kinevac

Generic Name: sincalide (SIN ka lide)

Brand Names: Kinevac

What is Kinevac (sincalide)?

Sincalide is a diagnostic agent that works by stimulating processes in specific organs of the body. Sincalide is injected in preparation for certain medical tests.

Sincalide is used to help diagnose disorders of the gallbladder or pancreas. It is also used to speed up digestion of barium, a contrast agent, given in preparation for x-ray examination of the intestines.

Sincalide may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Kinevac (sincalide)?

You should not receive sincalide if you are allergic to it, or if you have a blockage in your intestines.

Before you receive sincalide, tell your doctor if you have gallstones.

Your medical test or x-ray will be performed shortly after sincalide is injected.

Receiving this medication late in pregnancy may result in a miscarriage or premature labor. Before you receive sincalide, tell your doctor if you are pregnant.

What should I discuss with my health care provider before receiving Kinevac (sincalide)?

You should not receive sincalide if you are allergic to it, or if you have a blockage in your intestines.

Before you receive sincalide, tell your doctor if you have gallstones.

FDA pregnancy category B. Sincalide is not expected to harm an unborn baby during early pregnancy. However, receiving this medication late in pregnancy may result in a miscarriage or premature labor. Before you receive sincalide, tell your doctor if you are pregnant. It is not known whether sincalide passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How is sincalide given?

Sincalide is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting.

Your medical test or x-ray will be performed shortly after sincalide is injected.

What happens if I miss a dose?

Since sincalide is given by a healthcare professional as part of a medical test, you are not likely to miss a dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include nausea, vomiting, diarrhea, and stomach cramps.

What should I avoid before or after receiving Kinevac (sincalide)?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Kinevac (sincalide) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects are more likely, such as:

• 
  

  stomach pain or discomfort;

  
  


• 
  

  nausea, vomiting, diarrhea;

  
  


• 
  

  headache;

  
  


• 
  

  feeling light-headed or short of breath;

  
  


• 
  

  sweating, flushing (warmth, redness, or tingly feeling);

  
  


• 
  

  sneezing; or

  
  


• 
  

  mild skin rash.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Kinevac (sincalide)?

There may be other drugs that can interact with sincalide. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

More Kinevac resources

• Kinevac Side Effects (in more detail)
• Kinevac Use in Pregnancy & Breastfeeding
• Kinevac Support Group
• 0 Reviews for Kinevac - Add your own review/rating

• Kinevac Prescribing Information (FDA)


• Kinevac Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Kinevac with other medications

• Barium Meal Transit
• Gallbladder Contraction
• Pancreatic Secretion

Where can I get more information?

• Your doctor or pharmacist can provide more information about sincalide.

See also: Kinevac side effects (in more detail)

KGS-PE Liquid

Pronunciation: fen-ill-EF-rin/poe-TASS-ee-uhm gwie-ah-kole-SULL-foe-nate
Generic Name: Phenylephrine/Potassium Guaiacolsulfonate
Brand Name: KGS-PE

KGS-PE Liquid is used for:

Relieving symptoms of congestion, cough, and throat and airway irritation due to colds, flu, or hay fever. It may also be used for other conditions as determined by your doctor.

KGS-PE Liquid is a decongestant and expectorant combination. It works by constricting blood vessels and shrinking swollen and congested nasal tissues (mucous membranes) and by thinning and loosening mucus in the airway. This allows you to breathe more easily and makes coughs more productive.

Do NOT use KGS-PE Liquid if:

• you are allergic to any ingredient in KGS-PE Liquid


• you have severe high blood pressure, severe heart blood vessel disease, a rapid heartbeat, or severe heart problems


• you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using KGS-PE Liquid:

Some medical conditions may interact with KGS-PE Liquid. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a fast, slow, or irregular heartbeat


• if you have a history of adrenal gland problems (eg, tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, an enlarged prostate or other prostate problems, seizures, or an overactive thyroid


• if you have chronic cough

Some MEDICINES MAY INTERACT with KGS-PE Liquid. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Beta-blockers (eg, propranolol), catechol-O-methyltransferase (COMT) inhibitors (eg, tolcapone), furazolidone, indomethacin, MAO inhibitors (eg, phenelzine), or tricyclic antidepressants (eg, amitriptyline) because side effects of KGS-PE Liquid may be increased


• Digoxin or droxidopa because the risk of irregular heartbeat or heart attack may be increased


• Bromocriptine because side effects may be increased by KGS-PE Liquid


• Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because effectiveness may be decreased by KGS-PE Liquid

This may not be a complete list of all interactions that may occur. Ask your health care provider if KGS-PE Liquid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use KGS-PE Liquid:

Use KGS-PE Liquid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• KGS-PE Liquid may be taken with or without food.


• Take KGS-PE Liquid with a full glass of water unless your doctor directs otherwise.


• Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.


• If you miss a dose of KGS-PE Liquid, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use KGS-PE Liquid.

Important safety information:

• KGS-PE Liquid may cause dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to KGS-PE Liquid. Using KGS-PE Liquid alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.


• Do not take diet or appetite control medicines while you are taking KGS-PE Liquid without checking with you doctor.


• Do NOT exceed the recommended dose or use/take KGS-PE Liquid for longer than prescribed without checking with your doctor.


• KGS-PE Liquid contains phenylephrine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains phenylephrine. If it does or if you are uncertain, contact your doctor or pharmacist.


• If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.


• KGS-PE Liquid may interfere with certain lab test results. Make sure that all of your doctors and lab personnel know that you are taking KGS-PE Liquid.


• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using KGS-PE Liquid.


• Use KGS-PE Liquid with caution in the ELDERLY because they may be more sensitive to its effects.


• Caution is advised when using KGS-PE Liquid in CHILDREN because they may be more sensitive to its effects.


• PREGNANCY and BREAST-FEEDING: If you become pregnant while taking KGS-PE Liquid, discuss with your doctor the benefits and risks of using KGS-PE Liquid during pregnancy. It is unknown if KGS-PE Liquid is excreted in breast milk. Do not breast-feed while taking KGS-PE Liquid.

Possible side effects of KGS-PE Liquid:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; excitability; headache; nausea; nervousness or anxiety; trouble sleeping; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: KGS-PE side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of KGS-PE Liquid:

Store KGS-PE Liquid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep KGS-PE Liquid out of the reach of children and away from pets.

General information:

• If you have any questions about KGS-PE Liquid, please talk with your doctor, pharmacist, or other health care provider.


• KGS-PE Liquid is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about KGS-PE Liquid. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More KGS-PE resources

• KGS-PE Side Effects (in more detail)
• KGS-PE Use in Pregnancy & Breastfeeding
• KGS-PE Drug Interactions
• KGS-PE Support Group
• 0 Reviews · Be the first to review/rate this drug

Ketorolac Tromethamine Drops

Pronunciation: KEE-toe-ROLE-ak troe-METH-a-meen
Generic Name: Ketorolac Tromethamine
Brand Name: Acuvail

Ketorolac Tromethamine Drops are used for:

Treating eye pain and swelling following cataract surgery. It may also be used for other conditions as determined by your doctor.

Ketorolac Tromethamine Drops are a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking certain substances (prostaglandins) in the eye.

Do NOT use Ketorolac Tromethamine Drops if:

• you are allergic to any ingredient in Ketorolac Tromethamine Drops


• you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to aspirin, an NSAID (eg, ibuprofen, naproxen, celecoxib), or phenylacetic acid


• you are in late pregnancy

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ketorolac Tromethamine Drops:

Some medical conditions may interact with Ketorolac Tromethamine Drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have asthma, diabetes, bleeding problems, or rheumatoid arthritis


• if you have other eye problems (eg, dry eye syndrome, cornea problems, glaucoma or increased pressure in the eye), have had complicated eye surgery, or have had repeated eye surgeries within a short period of time


• if you have a herpes infection in the eye

Some MEDICINES MAY INTERACT with Ketorolac Tromethamine Drops. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), aspirin, corticosteroids (eg, prednisone), heparin, or NSAIDs (eg, ibuprofen) because the risk of side effects, such as bleeding, may be increased


• Topical corticosteroids for the eye (eg, dexamethasone) because they may slow or delay the healing of the eye

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ketorolac Tromethamine Drops may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ketorolac Tromethamine Drops:

Use Ketorolac Tromethamine Drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Ketorolac Tromethamine Drops. Talk to your pharmacist if you have questions about this information.


• Ketorolac Tromethamine Drops are only for the eye. Do not get it in your nose or mouth.


• To use Ketorolac Tromethamine Drops in the eye, first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eyelid for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.


• To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including the eye. Keep the container tightly closed.


• Each vial of Ketorolac Tromethamine Drops are intended for single use only. Throw away any unused medicine in the vial immediately after you have used your dose.


• If you are using other eye medicines, wait at least 5 minutes before applying them to the eye.


• Do not wear contact lenses while you are using Ketorolac Tromethamine Drops. Take care of your contact lenses as directed by the manufacturer. Check with your doctor before you use them.


• Do not use Ketorolac Tromethamine Drops if it is discolored or contains particles.


• If you miss a dose of Ketorolac Tromethamine Drops and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ketorolac Tromethamine Drops.

Important safety information:

• Ketorolac Tromethamine Drops may cause blurred vision. This effect may be worse if you take it with alcohol or certain medicines. Use Ketorolac Tromethamine Drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.


• Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor. Using Ketorolac Tromethamine Drops more than 24 hours before eye surgery or for more than 14 days after eye surgery may increase the risk of certain eye problems (eg, corneal problems). Some of these could be serious. Talk with your doctor if you have questions.


• If your symptoms do not get better within a few days or if they get worse, check with your doctor.


• Tell your doctor if you have a tendency to bleed easily.


• Contact your health care provider at once if you develop another eye condition (eg, trauma, eye surgery, infection) while taking Ketorolac Tromethamine Drops. It may be necessary to stop using Ketorolac Tromethamine Drops.


• Ketorolac Tromethamine Drops should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: Avoid using Ketorolac Tromethamine Drops late in pregnancy. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ketorolac Tromethamine Drops while you are pregnant. It is not known if Ketorolac Tromethamine Drops are found in breast milk after topical use. If you are or will be breast-feeding while you use Ketorolac Tromethamine Drops, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Ketorolac Tromethamine Drops:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; headache; increased tear production; swelling of the cornea and iris; temporary burning, irritation, pain, redness, stinging, or swelling of the eye.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); continuous pain, burning, irritation, stinging, redness, or swelling around the eyes; infection in the eye; unusual bleeding; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Ketorolac Tromethamine Drops:

Store Ketorolac Tromethamine Drops at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store the vials in the pouch provided with pouch ends folded closed. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Ketorolac Tromethamine Drops out of the reach of children and away from pets.

General information:

• If you have any questions about Ketorolac Tromethamine Drops, please talk with your doctor, pharmacist, or other health care provider.


• Ketorolac Tromethamine Drops are to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ketorolac Tromethamine Drops. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Ketorolac Tromethamine resources

• Ketorolac Tromethamine Use in Pregnancy & Breastfeeding
• Ketorolac Tromethamine Drug Interactions
• Ketorolac Tromethamine Support Group
• 2 Reviews for Ketorolac Tromethamine - Add your own review/rating

Compare Ketorolac Tromethamine with other medications

• Corneal Refractive Surgery
• Postoperative Ocular Inflammation
• Seasonal Allergic Conjunctivitis

Kinlytic

Generic Name: urokinase (URE oh KYE nase)

Brand Names: Abbokinase, Kinlytic

What is Kinlytic (urokinase)?

Urokinase is a man-made product developed using a protein that occurs naturally in the kidneys. Urokinase is a thrombolytic agent that works by dissolving blood clots.

Urokinase is used to treat blood clots in the lungs.

Urokinase may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Kinlytic (urokinase)?

You should not use this medication if you are allergic to urokinase, or if you have internal bleeding, a brain tumor or aneurysm, hemophilia or other bleeding disorder, arterial hypertension, or if you have had a recent stroke, surgery, organ transplant, or medical emergency .

Before you receive urokinase, tell your doctor if you have liver or kidney disease, diabetes, heart problems, if you are pregnant or recently gave birth, a history of stroke or stomach bleeding.

Tell your caregivers at once if you have a serious side effect such as easy bruising or bleeding, blood in your stools, coughing up blood, chest pain, sudden problems with vision or speech, swelling, discoloration of your fingers or toes, severe stomach pain, weak or shallow breathing, fever, chills, or flu symptoms.

Before you receive urokinase, tell your doctor if you are using a blood thinner such as warfarin (Coumadin), aspirin or an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), and others, or any medication used to prevent blood clots such as Kabikinase, Plavix, Ticlid, Persantine, Streptase, and others.

What should I discuss with my health care provider before I receive Kinlytic (urokinase)?

You should not use this medication if you are allergic to urokinase, or if you have:

• 
  

  internal bleeding;

  
  


• 
  

  a brain tumor;

  
  


• 
  

  a brain aneurysm (dilated blood vessel);

  
  


• 
  

  a bleeding or blood clotting disorder (such as hemophilia);

  
  


• 
  

  a condition called arterial hypertension;

  
  


• 
  

  if you have had a recent medical emergency requiring CPR (cardiopulmonary resuscitation);

  
  


• 
  

  if you have had a stroke, brain surgery, or spinal surgery within in the past 2 months.

  
  

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you receive urokinase, tell your doctor if you have:

• 
  

  a history of stroke;

  
  


• 
  

  severe liver or kidney disease;

  
  


• 
  

  eye problems caused by diabetes;

  
  


• 
  

  an infection of the lining of your heart (also called bacterial endocarditis);

  
  


• 
  

  a blood clot of your heart;

  
  


• 
  

  a recent history of stomach or intestinal bleeding;

  
  


• 
  

  if you are pregnant or have had a baby within the past 10 days; or

  
  


• 
  

  if you have had surgery or an organ transplant within the past 10 days.

  
  

FDA pregnancy category B. Urokinase is not expected to be harmful to an unborn baby. However, your doctor should know if you are pregnant before you receive this medication. It is not known whether urokinase passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Urokinase is made from human kidney cells and albumin (part of the blood) and it may contain viruses and other infectious agents that can cause disease. Although donated human blood is screened, tested, and treated to reduce the risk of it containing anything that could cause disease, there is still a small possibility it could transmit disease. Talk with your doctor about the risks and benefits of using this medication.

How is urokinase given?

Urokinase is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.

Urokinase is given slowly, usually over a period of 12 hours, using a continuous infusion pump.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving urokinase.

What happens if I miss a dose?

Since urokinase is given by a healthcare professional in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Because urokinase is given in a controlled clinical setting, an overdose is not expected to occur.

What should I avoid while receiving Kinlytic (urokinase)?

Avoid taking aspirin or ibuprofen (Motrin, Advil) to treat a fever shortly after you have received urokinase. These medications can increase your risk of bleeding. Ask your doctor about other methods of treating a fever.

Kinlytic (urokinase) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have a serious side effect such as:

• 
  

  easy bruising or bleeding (nosebleeds, bleeding gums, bleeding from a wound, incision, catheter, or needle injection );

  
  


• 
  

  bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  
  


• 
  

  chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  
  


• 
  

  sudden headache or problems with speech, vision, or balance;

  
  


• 
  

  fever, chills, flu symptoms, nausea, vomiting, back pain, or stomach pain;

  
  


• 
  

  drowsiness, confusion, mood changes, increased thirst, loss of appetite;

  
  


• 
  

  swelling, weight gain, feeling short of breath;

  
  


• 
  

  urinating less than usual or not at all;

  
  


• 
  

  red or purple discoloration of fingers or toes;

  
  


• 
  

  weak or shallow breathing, blue-colored lips or fingernails;

  
  


• 
  

  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure); or

  
  


• 
  

  pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate).

  
  

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Kinlytic (urokinase)?

The following drugs can interact with urokinase. Tell your doctor if you are using any of these:

• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  aspirin or an NSAID (non-steroidal anti-inflammatory drug) such as ibuprofen (Motrin, Advil), naproxen (Aleve, Naprosyn), diclofenac (Cataflam, Voltaren), etodolac (Lodine), indomethacin (Indocin), ketoprofen (Orudis), and others; or

  
  


• 
  

  medication used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), or ticlopidine (Ticlid).

  
  

This list is not complete and there may be other drugs that can interact with urokinase. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

More Kinlytic resources

• Kinlytic Side Effects (in more detail)
• Kinlytic Use in Pregnancy & Breastfeeding
• Kinlytic Drug Interactions
• Kinlytic Support Group
• 0 Reviews for Kinlytic - Add your own review/rating

• Kinlytic Prescribing Information (FDA)


• Kinlytic Monograph (AHFS DI)


• Kinlytic Advanced Consumer (Micromedex) - Includes Dosage Information

Compare Kinlytic with other medications

• Deep Vein Thrombosis
• Heart Attack
• Pulmonary Embolism
• Thrombotic/Thromboembolic Disorder

Where can I get more information?

• Your doctor or pharmacist can provide more information about urokinase.

See also: Kinlytic side effects (in more detail)

Kirkland Signature Sleep Aid

Dosage Form: tablet
Costco Wholesale Corp. Sleep Aid Tablets Drug Facts

Active ingredient (in each tablet)

Doxylamine succinate 25 mg

Purpose

Nighttime sleep-aid

Uses

• helps to reduce difficulty in falling asleep

Warnings

Ask a doctor before use if you have

• a breathing problem such as asthma, emphysema or chronic bronchitis


• glaucoma


• trouble urinating due to an enlarged prostate gland

Do not give

to children under 12 years of age

Ask a doctor or pharmacist before use if you are

taking any other drugs

When using this product

• avoid alcoholic beverages


• take only at bedtime

Stop use and ask a doctor if

• sleeplessness persists continuously for more than two weeks. Insomnia may be a symptom of serious underlying medical illness.

If pregnant or breast-feeding,

ask a health professional before use.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

• adults and children 12 years of age and over: take one tablet 30 minutes before going to bed; take once daily or as directed by a doctor


• children under 12 years of age: do not use

Other information

• store at 68°-77°F (20°-25°C)


• retain in carton until time of use


• see carton end panel for lot number and expiration date

Inactive ingredients

dibasic calcium phosphate, FD&C blue no. 1 aluminum lake, magnesium stearate, microcrystalline cellulose, sodium starch glycolate

Questions or comments?

1-800-774-2678

Principal Display Panel

Compare to Unisom® SleepTabs® active ingredient

Sleep Aid

Doxylamine Succinate Tablets, 25 mg

Nighttime Sleep Aid

Actual Size

Fall Asleep Fast!

Safe, Proven Effective

Just One Tablet Per Dose

Sleep Aid Tablets Carton

Kirkland Signature Sleep Aid  doxylamine succinate  tablet

Product Information Product Type HUMAN OTC DRUG NDC Product Code (Source) 63981-441 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength DOXYLAMINE SUCCINATE (DOXYLAMINE) DOXYLAMINE SUCCINATE 25 mg

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color BLUE Score no score Shape OVAL Size 10mm Flavor Imprint Code L441 Contains

Packaging # NDC Package Description Multilevel Packaging 1 63981-441-02 2 BOTTLE In 1 CARTON contains a BOTTLE 1 96 TABLET In 1 BOTTLE This package is contained within the CARTON (63981-441-02)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA040167	06/27/2003

Labeler - Costco Wholesale Company (103391843)

Revised: 06/2009Costco Wholesale Company

More Kirkland Signature Sleep Aid resources

• Kirkland Signature Sleep Aid Side Effects (in more detail)
• Kirkland Signature Sleep Aid Use in Pregnancy & Breastfeeding
• Drug Images
• Kirkland Signature Sleep Aid Drug Interactions
• Kirkland Signature Sleep Aid Support Group
• 8 Reviews for Kirkland Signature Sleep Aid - Add your own review/rating

Compare Kirkland Signature Sleep Aid with other medications

• Allergies
• Conjunctivitis, Allergic
• Hay Fever
• Insomnia
• Nasal Congestion
• Rhinorrhea
• Upper Respiratory Tract Infection

Ketoconazole/Hydrocortisone Gel

Pronunciation: KEE-toe-KON-a-zole/HYE-droe-KOR-ti-sone
Generic Name: Ketoconazole/Hydrocortisone
Brand Name: Xolegel CorePak

Ketoconazole/Hydrocortisone Gel is used for:

Treating a skin condition called seborrheic dermatitis. It may also help to reduce itching, redness, and swelling.

Ketoconazole/Hydrocortisone Gel kit contains an antifungal medicine and a topical corticosteroid. The antifungal works by killing the fungus causing the skin condition. The corticosteroid works by reducing skin inflammation, which helps relieve redness, swelling, itching, and irritation.

Do NOT use Ketoconazole/Hydrocortisone Gel if:

• you are allergic to any ingredient in Ketoconazole/Hydrocortisone Gel

Contact your doctor or health care provider right away if this applies to you.

Before using Ketoconazole/Hydrocortisone Gel:

Some medical conditions may interact with Ketoconazole/Hydrocortisone Gel. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding


• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement


• if you have allergies to medicines, foods, or other substances


• if you have a weakened immune system, liver problems, or the blood disease porphyria


• if you have a skin infection, measles, thinning of the skin, tuberculosis (TB), chickenpox, shingles, a positive TB skin test, or have recently had a vaccination

Some MEDICINES MAY INTERACT with Ketoconazole/Hydrocortisone Gel. Because little, if any, of Ketoconazole/Hydrocortisone Gel is absorbed into the blood, the risk of it interacting with another medicine is low.

Ask your health care provider if Ketoconazole/Hydrocortisone Gel may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ketoconazole/Hydrocortisone Gel:

Use Ketoconazole/Hydrocortisone Gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• An extra patient leaflet is available with Ketoconazole/Hydrocortisone Gel. Talk to your pharmacist if you have questions about this information.


• Wash your hands before and immediately after using Ketoconazole/Hydrocortisone Gel.


• To use the antifungal: Spread a thin layer of the medicine onto the affected area with the tips of your fingers. Gently rub it in. Be sure to cover the entire affected area and the healthy skin around it.


• Do not touch your eyes or nose while you are applying Ketoconazole/Hydrocortisone Gel.


• Wait for at least 20 minutes after you apply Ketoconazole/Hydrocortisone Gel before you apply makeup or sunscreen.


• Do not wash the area where you applied Ketoconazole/Hydrocortisone Gel for at least 3 hours after you apply it.


• To use the topical corticosteroid: Apply a small amount of medicine to the affected area. Gently rub it in until it is evenly distributed.


• Do not bandage or wrap the affected area unless directed otherwise by your doctor.


• If you miss a dose of Ketoconazole/Hydrocortisone Gel, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Ketoconazole/Hydrocortisone Gel.

Important safety information:

• Ketoconazole/Hydrocortisone Gel is for external use only. Do not get it in your eyes, nose, or mouth. If you get it in your eyes, rinse at once with cool tap water. Do not get Ketoconazole/Hydrocortisone Gel in your vagina.


• Do not use Ketoconazole/Hydrocortisone Gel for other skin conditions at a later time.


• Ketoconazole/Hydrocortisone Gel is flammable. Do not store or use near an open flame. Do not smoke during or right after use of Ketoconazole/Hydrocortisone Gel.


• Check with your doctor before receiving vaccinations while you are using Ketoconazole/Hydrocortisone Gel.


• Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Ketoconazole/Hydrocortisone Gel, especially if the child is using a large amount of it or using it for a long period of time.


• Ketoconazole/Hydrocortisone Gel should be used with extreme caution in CHILDREN younger than 12 years old; safety and effectiveness in these children have not been confirmed.


• PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Ketoconazole/Hydrocortisone Gel while you are pregnant. It is not known if Ketoconazole/Hydrocortisone Gel is found in breast milk after topical use. If you are or will be breast-feeding while you use Ketoconazole/Hydrocortisone Gel, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Ketoconazole/Hydrocortisone Gel:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild skin irritation or dryness; mild, temporary burning or stinging at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); infection; new or worsening irritation, pain, redness, blistering, or severe burning at the application site; skin thinning or discoloration.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of Ketoconazole/Hydrocortisone Gel:

Store Ketoconazole/Hydrocortisone Gel at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do NOT store near an open flame. Keep Ketoconazole/Hydrocortisone Gel out of the reach of children and away from pets.

General information:

• If you have any questions about Ketoconazole/Hydrocortisone Gel, please talk with your doctor, pharmacist, or other health care provider.


• Ketoconazole/Hydrocortisone Gel is to be used only by the patient for whom it is prescribed. Do not share it with other people.


• If your symptoms do not improve or if they become worse, check with your doctor.


• Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Ketoconazole/Hydrocortisone Gel. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Ketoconazole/Hydrocortisone resources

• Ketoconazole/Hydrocortisone Use in Pregnancy & Breastfeeding
• Ketoconazole/Hydrocortisone Drug Interactions
• Ketoconazole/Hydrocortisone Support Group
• 0 Reviews for Ketoconazole/Hydrocortisone - Add your own review/rating

Compare Ketoconazole/Hydrocortisone with other medications

• Seborrheic Dermatitis

ketoconazole

Generic Name: ketoconazole (KEE toe KON a zole)

Brand Names: Nizoral

What is ketoconazole?

Ketoconazole is an antifungal antibiotic.

Ketoconazole is used to treat infections caused by fungus, which can invade any part of the body including the mouth, throat, esophagus, lungs, bladder, or skin.

Ketoconazole may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about ketoconazole?

You should not use this medication if you are allergic to ketoconazole, or if you are also taking triazolam (Halcion).

Before taking ketoconazole, tell your doctor if you have liver disease, kidney disease, a heart rhythm disorder, decreased stomach acid (achlorhydria), or a history of "Long QT syndrome."

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ketoconazole will not treat a viral infection such as the common cold or flu.

Avoid taking antacids or stomach acid reducers (Tagamet, Pepcid, Axid, Zantac, and others) for at least 2 hours after you have taken your dose of ketoconazole. These medications can make it harder for the ketoconazole tablet to dissolve in your stomach.

Avoid drinking alcohol. It may cause unpleasant side effects while you are taking ketoconazole.

What should I discuss with my healthcare provider before taking ketoconazole?

You should not use this medication if you are allergic to ketoconazole, or if you are also taking triazolam (Halcion).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely take ketoconazole:

• 
  

  decreased stomach acid (achlorhydria);

  
  


• 
  

  liver disease;

  
  


• 
  

  kidney disease;

  
  


• 
  

  a heart rhythm disorder; or

  
  


• 
  

  a personal or family history of "Long QT syndrome."

  
  

FDA pregnancy category C. It is not known whether ketoconazole is harmful to an unborn baby. Before you take this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Ketoconazole may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take ketoconazole?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Ketoconazole works best if you take it with food. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Ketoconazole will not treat a viral infection such as the common cold or flu.

To be sure this medication is not causing harmful effects, your liver function may need to be checked with blood tests on a regular basis. Do not miss any scheduled appointments.

Store ketoconazole at room temperature away from moisture and heat.

See also: Ketoconazole dosage (in more detail)

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a ketoconazole overdose are not known.

What should I avoid while taking ketoconazole?

Avoid taking antacids or stomach acid reducers (Tagamet, Pepcid, Axid, Zantac, and others) for at least 2 hours after you have taken your dose of ketoconazole. These medications can make it harder for the ketoconazole tablet to dissolve in your stomach.

Avoid drinking alcohol. It may cause unpleasant side effects while you are taking ketoconazole.

Ketoconazole side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

• 
  

  dizziness, fainting, fast or pounding heartbeat;

  
  


• 
  

  easy bruising or bleeding, unusual weakness;

  
  


• 
  

  numbness or tingly feeling;

  
  


• 
  

  severe depression, confusion, or thoughts of hurting yourself; or

  
  


• 
  

  nausea, stomach pain, low fever, loss of appetite, weakness, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

  
  

Less serious side effects may include:

• 
  

  mild nausea, vomiting, or stomach pain;

  
  


• 
  

  mild itching or skin rash;

  
  


• 
  

  headache;

  
  


• 
  

  dizziness;

  
  


• 
  

  breast swelling; or

  
  


• 
  

  impotence or loss of interest in sex.

  
  

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ketoconazole Dosing Information

Usual Adult Dose for Oral Thrush:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for 1-2 weeks.

Usual Adult Dose for Dermatophytosis:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for 4 weeks.

Usual Adult Dose for Blastomycosis:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for at least 6 months.

Usual Adult Dose for Coccidioidomycosis:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for at least 6 months.

Usual Adult Dose for Histoplasmosis:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for at least 6 months.

Usual Adult Dose for Paracoccidioidomycosis:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for at least 6 months.

Usual Adult Dose for Chronic Mucocutaneous Candidiasis:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for 3-12 months. Patients usually require maintenance therapy.

Usual Adult Dose for Esophageal Candidiasis:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for 2-3 weeks.

Usual Adult Dose for Onychomycosis -- Fingernail:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for 6-12 months.

Usual Adult Dose for Onychomycosis -- Toenail:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for 6-12 months.

Usual Adult Dose for Vaginal Candidiasis:

Initial dose: 200 mg orally once a day.
May be increased to 400 mg once a day for more severe or resistant infections. Treatment should be continued for approximately 1 to 2 weeks and until tests indicate the resolution of the infection.

What other drugs will affect ketoconazole?

Many drugs can interact with ketoconazole. Below is just a partial list. Tell your doctor if you are using:

• 
  

  acetaminophen (Tylenol);

  
  


• 
  

  cyclosporine (Gengraf, Sandimmune, Neoral);

  
  


• 
  

  clopidogrel (Plavix);

  
  


• 
  

  digoxin (digitalis, Lanoxin);

  
  


• 
  

  tacrolimus ((Prograf);

  
  


• 
  

  loratadine (Alavert, Claritin, Tavist ND);

  
  


• 
  

  methylprednisolone (Medrol);

  
  


• 
  

  phenytoin (Dilantin);

  
  


• 
  

  rifampin (Rifadin, Rifater, Rifamate, Rimactane);

  
  


• 
  

  diabetes medication you take by mouth;

  
  


• 
  

  a sedative such as midazolam (Versed);

  
  


• 
  

  a blood thinner such as warfarin (Coumadin);

  
  


• 
  

  cancer medications;

  
  


• 
  

  birth control pills or hormone replacement therapy;

  
  


• 
  

  methotrexate (Rheumatrex, Trexall);

  
  


• 
  

  cholesterol medications such as niacin (Advicor), atorvastatin (Lipitor), lovastatin (Altocor, Mevacor), simvastatin (Zocor), and others; or

  
  


• 
  

  medications to treat HIV or AIDS.

  
  

This list is not complete and there are many other drugs that can interact with ketoconazole. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

More ketoconazole resources

• Ketoconazole Dosage
• Ketoconazole Use in Pregnancy & Breastfeeding
• Drug Images
• Ketoconazole Drug Interactions
• Ketoconazole Support Group
• 4 Reviews for Ketoconazole - Add your own review/rating

• ketoconazole Advanced Consumer (Micromedex) - Includes Dosage Information


• Ketoconazole Professional Patient Advice (Wolters Kluwer)


• Ketoconazole MedFacts Consumer Leaflet (Wolters Kluwer)


• Ketoconazole Monograph (AHFS DI)


• Nizoral Prescribing Information (FDA)


• Nizoral Consumer Overview

Compare ketoconazole with other medications

• Blastomycosis
• Chronic Mucocutaneous Candidiasis
• Coccidioidomycosis
• Dermatophytosis
• Esophageal Candidiasis
• Histoplasmosis
• Onychomycosis, Fingernail
• Onychomycosis, Toenail
• Oral Thrush
• Paracoccidioidomycosis
• Tinea Versicolor
• Vaginal Yeast Infection

Where can I get more information?

• Your pharmacist can provide more information about ketoconazole.

Kirklands Childrens Aller-Tec

Dosage Form: oral solution
Costco Wholesale Corp. Children's Aller-Tec(tm) Oral Solution Drug Facts

Active ingredient (in each 5 mL teaspoonful)

Cetirizine HCl 5 mg

Purpose

Antihistamine

Uses

temporarily relieves these symptoms due to hay fever or other upper respiratory allergies:

• runny nose


• sneezing


• itchy, watery eyes


• itching of the nose or throat

Warnings

Do not use

if you have ever had an allergic reaction to this product or any of its ingredients or to an antihistamine containing hydroxyzine.

Ask a doctor before use if you have

liver or kidney disease. Your doctor should determine if you need a different dose.

Ask a doctor or pharmacist before use if you are

taking tranquilizers or sedatives.

When using this product

• drowsiness may occur avoid alcoholic drinks


• alcohol, sedatives, and tranquilizers may increase drowsiness


• be careful when driving a motor vehicle or operating machinery

Stop use and ask a doctor if

an allergic reaction to this product occurs. Seek medical help right away.

If pregnant or breast-feeding:

• if breast-feeding: not recommended


• if pregnant: ask a health professional before use.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

• use only with enclosed dosing cup

adults and children 6 years and over	1 teaspoonful (5 mL) or 2 teaspoonfuls (10 mL) once daily depending upon severity of symptoms; do not take more than 2 teaspoonfuls (10 mL) in 24 hours.
adults 65 years and over	1 teaspoonful (5 mL) once daily; do not take more than 1 teaspoonful (5 mL) in 24 hours.
children 2 to under 6 years of age	1/2 teaspoonful (2.5 mL) once daily. If needed, dose can be increased to a maximum of 1 teaspoonful (5 mL) once daily or 1/2 teaspoonful (2.5 mL) every 12 hours. Do not give more than 1 teaspoonful (5 mL) in 24 hours.
children under 2 years of age	ask a doctor
consumers with liver or kidney disease	ask a doctor

Other information

• do not use if carton is opened, or if printed neckband is broken or missing


• store between 20° to 25°C (68° to 77°F)

Inactive ingredients

acetic acid, artificial grape flavor, glycerin, methylparaben, natural banana flavor, propylene glycol, propylparaben, sodium acetate, sucrose, water

Questions or comments?

1-800-774-2678

Principal Display Panel

Compare to Children's Zyrtec® active ingredient

Children's

Aller-Tec(tm)

Cetirizine Hydrochloride Oral Solution 1 mg/mL

Antihistamine

Indoor & Outdoor Allergies

Allergy

24 Hour

Relief of:

Itchy, Watery Eyes

Itchy Throat or Nose

Sneezing

Runny Nose

2 years & older

Grape

Children's Aller-Tec(tm) Carton

KIRKLANDS CHILDRENS ALLER TEC  cetirizine  liquid

Product Information Product Type HUMAN OTC DRUG NDC Product Code (Source) 63981-974 Route of Administration ORAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength CETIRIZINE HYDROCHLORIDE (CETIRIZINE) CETIRIZINE HYDROCHLORIDE 5 mg  in 5 mL

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color YELLOW (Pale Yellow) Score      Shape Size Flavor GRAPE Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 63981-974-43 2 BOTTLE In 1 CARTON contains a BOTTLE (63981-974-34) 1 63981-974-34 240 mL In 1 BOTTLE This package is contained within the CARTON (63981-974-43)

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
ANDA	ANDA090254	08/14/2009

Labeler - Costco Wholesale Company (103391843)

Revised: 09/2009Costco Wholesale Company

More Kirklands Childrens Aller-Tec resources

• Kirklands Childrens Aller-Tec Side Effects (in more detail)
• Kirklands Childrens Aller-Tec Use in Pregnancy & Breastfeeding
• Drug Images
• Kirklands Childrens Aller-Tec Drug Interactions
• Kirklands Childrens Aller-Tec Support Group
• 73 Reviews for Kirklands Childrens Aller-Tec - Add your own review/rating

Compare Kirklands Childrens Aller-Tec with other medications

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Klonopin Wafers

Generic Name: clonazepam (Oral route)

kloe-NAZ-e-pam

Commonly used brand name(s)

In the U.S.

• Klonopin


• Klonopin Wafers

Available Dosage Forms:

• Tablet, Disintegrating


• Solution


• Tablet

Therapeutic Class: Antianxiety

Pharmacologic Class: Benzodiazepine, Short or Intermediate Acting

Uses For Klonopin Wafers

Clonazepam is used alone or together with other medicines to treat certain seizure (convulsive) disorders (e.g., Lennox-Gastaut syndrome, akinetic or myoclonic seizures). It is also used to treat panic disorder in some patients. Clonazepam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

Before Using Klonopin Wafers

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of clonazepam in children with seizure disorders. However, safety and efficacy in children with panic disorder have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of clonazepam in the elderly. However, elderly patients are more likely to have confusion and severe drowsiness, or age-related heart, liver, or kidney problems, which may require caution and an adjustment in the dose for patients receiving clonazepam.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Alfentanil


• Amobarbital


• Anileridine


• Aprobarbital


• Butabarbital


• Butalbital


• Carisoprodol


• Chloral Hydrate


• Chlorzoxazone


• Codeine


• Dantrolene


• Ethchlorvynol


• Fentanyl


• Fospropofol


• Hydrocodone


• Hydromorphone


• Levorphanol


• Meperidine


• Mephenesin


• Mephobarbital


• Meprobamate


• Metaxalone


• Methocarbamol


• Methohexital


• Morphine


• Morphine Sulfate Liposome


• Oxycodone


• Oxymorphone


• Pentobarbital


• Phenobarbital


• Primidone


• Propoxyphene


• Remifentanil


• Secobarbital


• Sodium Oxybate


• Sufentanil


• Tapentadol


• Thiopental


• Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Amiodarone


• Carbamazepine


• Desipramine


• Ginkgo


• Nevirapine


• Ritonavir


• St John's Wort


• Theophylline

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

• Ethanol

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

• Depression, history of or


• Lung or breathing problems—Use with caution. May make these conditions worse.

• Glaucoma, acute narrow angle or untreated open-angle or


• Liver disease, severe—Should not be used in patients with these conditions.

• Kidney disease or


• Liver disease—Use with caution. The effects may be increased because of slower removal of the medicine from the body.

Proper Use of clonazepam

This section provides information on the proper use of a number of products that contain clonazepam. It may not be specific to Klonopin Wafers. Please read with care.

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

If you or your child are using the orally disintegrating tablet (wafer), make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil. Do not push the tablet through the foil. Do not break or split the tablet. Place the tablet in your mouth. It should melt quickly. After the tablet has melted, you may take a sip of water.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (tablets or disintegrating tablets):
  
  • For seizures:
    
    • Adults, teenagers, and children 10 years of age and older—At first, 0.5 milligram (mg) three times a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 20 mg per day.
    
    
    • Infants and children younger than 10 years of age and weighing 30 kilograms (kg)—Dose is based on body weight and must be determined by your doctor.
    
    
  
  
  • For panic disorder:
    
    • Adults—At first, 0.25 milligram (mg) two times a day. Your doctor may adjust your dose if needed. However, the dose is usually not more than 4 mg per day.
    
    
    • Children—Use and dose must be determined by your doctor.
    
    
  
  

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using Klonopin Wafers

It is very important that your doctor check the progress of you or your child at regular visits to see if the medicine is working properly and to allow for changes in the dose. Blood tests may be needed to check for any unwanted effects.

Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. Your doctor may want you to join a pregnancy registry for patients taking a seizure medicine.

This medicine may cause drowsiness, trouble with thinking, trouble with controlling movements, or trouble with seeing clearly. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to think or see well.

This medicine may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. If you, your child, or your caregiver notice any of these side effects, tell your doctor or your child's doctor right away.

If you or your child have been taking this medicine in large doses or for a long time, do not stop taking it without checking first with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms, such as convulsions (seizures), hallucinations, stomach or muscle cramps, tremors, or unusual behavior.

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates (used for seizures); muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Klonopin Wafers Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

• Body aches or pain


• chills


• cough


• difficulty with breathing


• discouragement


• dizziness


• ear congestion


• feeling sad or empty


• fever


• headache


• irritability


• lack of appetite


• loss of interest or pleasure


• loss of voice


• nasal congestion


• poor coordination


• runny nose


• shakiness and unsteady walk


• sleepiness or unusual drowsiness


• sneezing


• sore throat


• tiredness


• trouble with concentrating


• trouble with sleeping


• unsteadiness, trembling, or other problems with muscle control or coordination


• unusual tiredness or weakness

Less common

• Being forgetful


• bladder pain


• bloody or cloudy urine


• changes in patterns and rhythms of speech


• diarrhea


• difficult, burning, or painful urination


• frequent urge to urinate


• general feeling of discomfort or illness


• joint pain


• loss of appetite


• lower back or side pain


• mood or mental changes


• muscle aches and pains


• nausea


• nervousness


• problems in urination or increase in the amount of urine


• shivering


• slurred speech


• sore throat


• sweating


• trouble with speaking


• vomiting

Rare

• Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings


• changes in skin color


• chest pain or discomfort


• cold sweats


• colds


• confusion


• cough or hoarseness


• difficulty with sleeping


• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position


• excessive dreaming


• excessive muscle tone


• excitement


• falling


• fast, irregular, pounding, or racing heartbeat or pulse


• feeling mad


• feeling of unreality


• flu-like symptoms


• headache, severe and throbbing


• lack of feeling or emotion


• lack or loss of self-control


• muscle stiffness


• muscle tension or tightness


• nightmares


• pain, inflammation, or swelling in the calves, shoulders, or hands


• pain or swelling in the arms or legs without any injury


• pain, tenderness, or swelling of the foot or leg


• partial or slight paralysis


• scaling


• sense of detachment from self or body


• shakiness in the legs, arms, hands, or feet


• shortness of breath


• skin rash


• sleeplessness


• swelling around the eyes


• swelling of the face, ankle, foot, or knees


• thoughts of killing oneself changes in behavior


• tightness in the chest


• trembling or shaking of the hands or feet


• troubled breathing


• unable to sleep


• uncaring


• vision changes


• wheezing

Incidence not known

• Anxiety


• black, tarry stools


• bleeding gums


• blood in the urine or stools


• change in consciousness


• chest congestion


• difficulty with coordination


• double vision


• drowsiness


• dry mouth


• feeling that others are watching you or controlling your behavior


• feeling that others can hear your thoughts


• feeling, seeing, or hearing things that are not there


• hyperventilation


• irregular, fast, slow, or shallow breathing


• irregular, twisting uncontrolled movement of the face, hands, arms, or legs


• loss of consciousness


• loss of interest or pleasure


• loss of memory


• loss of strength or energy


• loss of voice


• muscle weakness


• pale or blue lips, fingernails, or skin


• pinpoint red spots on the skin


• problems with memory


• restlessness


• right upper abdominal pain and fullness


• severe mood or mental changes


• sores, ulcers, or white spots on the lips or in the mouth


• swollen glands


• troubled breathing with exertion


• uncontrolled eye movements


• unusual behavior


• unusual bleeding or bruising


• unusual weak feeling


• vivid dreams


• weight loss or gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

• Decreased interest in sexual intercourse


• difficulty with swallowing


• dryness or soreness of the throat


• heavy bleeding


• hives


• inability to have or keep an erection


• longer than usual time to ejaculation of semen


• loss in sexual ability, desire, drive, or performance


• pain or tenderness around the eyes and cheekbones


• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue


• voice changes

Rare

• Acid or sour stomach


• ankle, knee, or great toe joint pain


• belching


• bleeding after defecation


• blistering, burning, crusting, dryness, or flaking of the skin


• bloated


• blurred or loss of vision


• decrease or change in vision


• difficulty with moving


• disturbed color perception


• double vision


• dryness of the eyes


• earache


• excess air or gas in stomach or intestines


• feeling of constant movement of self or surroundings


• feeling of warmth


• frequent bowel movements


• full feeling


• hair loss or thinning of the hair


• halos around lights


• heartburn


• increased watering of the mouth


• indigestion


• irregularities in menstruation


• itching in genital or other skin areas


• itching, scaling, severe redness, soreness, or swelling of the skin


• joint stiffness or swelling


• leg or muscle cramps


• loss of taste


• night blindness


• nosebleeds


• overbright appearance of lights


• pain in the breasts or pelvic area


• pain in the leg, nape, or back


• passing gas


• red, sore eyes


• redness of the face, neck, arms, and occasionally, upper chest


• redness or swelling in the ear


• sensation of spinning


• skin rash cracks in the skin at the corners of the mouth


• smaller amount of semen ejaculated than usual


• sore on the edge of the eyelid


• soreness or redness around the fingernails and toenails


• stomach discomfort, upset, or pain


• thickening of the tongue


• thirst


• tooth disorder


• toothache


• tunnel vision


• twitching of the eyes


• uncomfortable swelling around the anus


• worsening of acne

Incidence not known

• Burning feeling in the chest or stomach


• difficulty having a bowel movement (stool)


• increased appetite


• increased hair growth, especially on the face


• increased in sexual ability, desire, drive, or performance


• increased interest in sexual intercourse


• sore gums


• tenderness in the stomach area

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Klonopin side effects (in more detail)

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More Klonopin Wafers resources

• Klonopin Wafers Side Effects (in more detail)
• Klonopin Wafers Use in Pregnancy & Breastfeeding
• Drug Images
• Klonopin Wafers Drug Interactions
• Klonopin Wafers Support Group
• 10 Reviews for Klonopin - Add your own review/rating

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